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Rauwolscine (hydrochloride)

Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.

Product Specifications

CAS Number

6211-32-1

Product Name Alternative

α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride

UNSPSC

12352005

Hazard Statement

H300, H310, H330

Target

Adrenergic Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Rauwolscine_hydrochloride.html

Purity

99.95

Solubility

DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

[H]Cl.[H][C@]12C(NC3=C4C=CC=C3)=C4CCN1C[C@@]5([H])CC[C@H](O)[C@@H](C(OC)=O)[C@]5(C2)[H]

Molecular Formula

C21H27ClN2O3

Molecular Weight

390.90

Precautions

H300, H310, H330

References & Citations

[1]Perry BD, et al. [3H]rauwolscine (alpha-yohimbine) : a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. 1981 Dec 17;76 (4) :461-4.|[2]De Vos H, et al. [3H]rauwolscine behaves as an agonist for the 5-HT1A receptors in human frontal cortex membranes. Eur J Pharmacol. 1991 May 25;207 (1) :1-8.|[3]Wainscott DB, et al. [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357 (1) :17-24.|[4]Neylon CB, et al. [3H]-rauwolscine binding to alpha 2-adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species. Br J Pharmacol. 1985 Jun;85 (2) :349-59.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

α adrenergic receptor

Frequently Asked Questions

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