1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine

1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells [1]. Serum levels of 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine are elevated in patients with malignant breast cancer compared to healthy controls[2].

Product Specifications

CAS Number

[123060-40-2]

Product Name Alternative

14:0 Lyso PE; 1-Myristoyl-2-hydroxy-sn-glycero-3-PE; 1-Tetradecanoyl-sn-glycero-3-phosphoethanolamine

UNSPSC

12352200

Hazard Statement

H302-H315-H319-H335

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCCC(OC[C@@H](O)COP(OCCN)(O)=O)=O

Molecular Formula

C19H40NO7P

Molecular Weight

425.50

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lee, J.M., Park, S.J., and Im, D.S. Lysophosphatidylethanolamine increases intracellular Ca2+ through LPA1 in PC-12 neuronal cells. Biochem. Biophys. Res. Commun. 461 (2), 378-382 (2015) .|[2]More, T.H., Bagadi, M., RoyChoudhury, S., et al. Comprehensive quantitative lipidomic approach to investigate serum phospholipid alterations in breast cancer. Metabolomics 13:3, (2017) .