CM-352
CM-352 (compound 5) is an inhibitor of matrix metalloproteinases (MMPs) (MMP-3: IC50=15 nM; MMP-10: IC50=12 nM) . CM-352 has significant antifibrinolytic activity (EC50=0.7 nM) and can significantly prolong blood coagulation time. CM-352 can be used in anti-bleeding research[1].
Product Specifications
CAS Number
1664361-37-8
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cm-352.html
Smiles
O=S([C@]1(CC2(CCNCC2)CC1)C(NO)=O)(C3=CC=C(C=C3)OC4=CC=C(C=C4)C(NC)=O)=O
Molecular Formula
C24H29N3O6S
Molecular Weight
487.57
References & Citations
[1]Orbe J, et al. Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead[J]. Journal of Medicinal Chemistry, 2015, 58 (5) : 2465-2488.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-10; MMP-3
Available Sizes
Frequently Asked Questions
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