PDdEC-NB
PDdEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC) .
Product Specifications
CAS Number
[1956318-90-3]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pddec-nb.html
Purity
97.63
Solubility
10 mM in DMSO
Smiles
O=C(OC1=CC=C([N+]([O-])=O)C=C1)OCC(SSC2=NC=CC=C2)(C)C
Molecular Formula
C16H16N2O5S2
Molecular Weight
380.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Flygare, John, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods.WO 2016040825 A1 20160317.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Available Sizes
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