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Vat-Cit-PAB-Monomethyl Dolastatin 10

Vat-Cit-PAB-Monomethyl Dolastatin 10 is a agent-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.

Product Specifications

CAS Number

[1415329-13-3]

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vat-cit-pab-monomethyl-dolastatin-10.html

Solubility

10 mM in DMSO

Smiles

CC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N2CCC[C@@H]2[C@H](OC)[C@@H](C)C(N[C@H](C3=NC=CS3)CC4=CC=CC=C4)=O)=O)=O)=O)=O)C=C1)=O)=O

Molecular Formula

C60H93N11O11S

Molecular Weight

1176.51

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8 (2) :114-9.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Auristatin

Available Sizes

Curated Selection

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