JAK/HDAC-IN-1

JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. JAK/HDAC-IN-1 shows IC50s of 4 and 2 nM for JAK2 and HDAC, respectively[1].

Product Specifications

CAS Number

[2284621-75-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HDAC; JAK

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Concentration

10mM

Purity

98.63

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(NC2=NC(NC3=CN(CCCCCC(NO)=O)N=C3)=NC=C2Cl)C=C1

Molecular Formula

C19H21Cl2N7O2

Molecular Weight

450.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62 (8) :3898-3923.