BMS-819881

BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.

Product Specifications

CAS Number

[1197420-05-5]

UNSPSC

12352005

Target

Cytochrome P450; MCHR1 (GPR24)

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/BMS-819881.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C2=CC(N=CN(C3=CC(OC)=C(OC[C@H](O)C4CC4)C=C3)C5=O)=C5S2)C=C1

Molecular Formula

C24H21ClN2O4S

Molecular Weight

468.95

References & Citations

[1]Washburn WN, et al. Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate. J Med Chem. 2014 Sep 25;57 (18) :7509-22.