NVS-CRF38

NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility. IC50 value: Target: CRF1 antagonist

Product Specifications

CAS Number

[1207258-55-6]

UNSPSC

12352005

Target

CRFR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/nvs-crf38.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(C)=C(C2=C(C)OC3=C(N4N=C(C)N=C4C)C(C)=NN32)C=C1

Molecular Formula

C19H21N5O2

Molecular Weight

351.40

References & Citations

[1]Stringer RA, et al. Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica. 2014 Apr 3.|[2]Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42 (7) :1117-24.