ITGA5 (heavy chain, Cleaved-Arg894) rabbit pAb

Function: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. similarity: Belongs to the integrin alpha chain family. similarity: Contains 7 FG-GAP repeats. subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.

Product Specifications

Background

Function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions., similarity:Belongs to the integrin alpha chain family., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.

UniProt

P08648

Swiss Prot

P08648

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human ITGA5 (heavy chain, Cleaved-Arg894)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Molecular Weight

94 110kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

94 110kD

Fragment

IgG

Subcellular Location

Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .

Other Product Names

Integrin alpha-5 (CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]