Pitolisant (oxalate)

Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM) .

Product Specifications

CAS Number

[362665-57-4]

Product Name Alternative

Tiprolisant oxalate

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/pitolisant-oxalate.html

Purity

98.50

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1.O=C(O)C(O)=O

Molecular Formula

C19H28ClNO5

Molecular Weight

385.88

References & Citations

[1]Ligneau X, et al. BF2.649 [1-{3-[3- (4-Chlorophenyl) propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320 (1) :365-75.|[2]Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis. 2016 Oct;31 (5) :1023-9.|[3]Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H? receptor inverse agonist/antagonist compared with Modafinil. Br J Pharmacol. 2013 Jun;169 (3) :632-44.