Viltolarsen (sodium)
Product Specifications
Product Name Alternative
NS-065/NCNP-01 (sodium)
UNSPSC Description
Viltolarsen (NS-065/NCNP-01) sodium is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen sodium binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen sodium has the potential for Duchenne muscular dystrophy (DMD) research[1][2].
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/viltolarsen-sodium.html
Purity
92.75
Solubility
10 mM in H2O
Smiles
[Viltolarsen (sodium)]
Molecular Weight
7386.42
References & Citations
[1]Sohita Dhillon. Viltolarsen: First Approval. Drugs. 2020 Jul;80(10):1027-1031. |[2]Naoki Watanabe, et al. NS-065/NCNP-01: An Antisense Oligonucleotide for Potential Treatment of Exon 53 Skipping in Duchenne Muscular Dystrophy. Mol Ther Nucleic Acids. 2018 Dec 7:13:442-449.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132586A/Viltolarsen-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132586A/
Clinical Information
Phase 4
Available Sizes
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