Viltolarsen (sodium)
Viltolarsen (NS-065/NCNP-01) sodium is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen sodium binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen sodium has the potential for Duchenne muscular dystrophy (DMD) research[1][2].
Product Specifications
Product Name Alternative
NS-065/NCNP-01 (sodium)
UNSPSC
12352208
Target
Dystrophin; Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/viltolarsen-sodium.html
Purity
95.25
Solubility
10 mM in H2O
Smiles
[Viltolarsen(sodium)]
Molecular Formula
C244H360N113Na21O88P20
Molecular Weight
6924.8 (free acid)
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 4
Available Sizes
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Sik1, CT (Sik1, Msk, Sik, Snf1lk, Serine/threonine-protein kinase SIK1, HRT-20, Myocardial SNF1-like kinase, Salt-inducible kinase 1, Serine/threonine-protein kinase SNF1-like kinase 1) (PE)