Psicofuranine

Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth[1][2].

Product Specifications

CAS Number

[1874-54-0]

UNSPSC

12352005

Hazard Statement

H302+H312, H319

Target

Antibiotic; Bacterial; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/psicofuranine.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

OC[C@@H]1[C@H]([C@H]([C@@](CO)(O1)N2C=NC3=C2N=CN=C3N)O)O

Molecular Formula

C11H15N5O5

Molecular Weight

297.27

Precautions

H302+H312, H319

References & Citations

[1]cConkey GA. Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase. Exp Parasitol. 2000 Jan;94 (1) :23-32.|[2]UDAKA S, et al. INHIBITION OF PARENTAL AND MUTANT XANTHOSINE 5'-PHOSPHATE AMINASES BY PSICOFURANINE. J Biol Chem. 1963 Aug;238:2797-803.