Psicofuranine
Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth[1][2].
Product Specifications
CAS Number
1874-54-0
UNSPSC
12352005
Hazard Statement
H302+H312, H319
Target
Antibiotic; Bacterial; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/psicofuranine.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic; warming)
Smiles
OC[C@@H]1[C@H]([C@H]([C@@](CO)(O1)N2C=NC3=C2N=CN=C3N)O)O
Molecular Formula
C11H15N5O5
Molecular Weight
297.27
Precautions
H302+H312, H319
References & Citations
[1]cConkey GA. Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase. Exp Parasitol. 2000 Jan;94 (1) :23-32.|[2]UDAKA S, et al. INHIBITION OF PARENTAL AND MUTANT XANTHOSINE 5'-PHOSPHATE AMINASES BY PSICOFURANINE. J Biol Chem. 1963 Aug;238:2797-803.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
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