BACE1-IN-10
BACE1-IN-10 is a potent BACE1 Inhibitor. BACE1-IN-10 shows sub-micromolar activity against recombinant BACE1 (rBACE1) [1].
Product Specifications
CAS Number
2799658-44-7
UNSPSC
12352209
Target
Beta-secretase
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bace1-in-10.html
Solubility
10 mM in DMSO
Smiles
CC[C@@H]([C@@H](C(N[C@H](C(N[C@H]([C@@H](CNC1=CC=C(C=C1)CC(O)=O)O)CC(C)C)=O)CC2=CC=CS2)=O)NC([C@H](CCC(O)=O)N)=O)C
Molecular Formula
C33H49N5O8S
Molecular Weight
675.84
References & Citations
[1]Kazuya Kobayashi, et al. Structure-activity relationship study of hydroxyethylamine isostere and P1' site structure of peptide mimetic BACE1 inhibitors. Bioorg Med Chem. 2021 Nov 15;50:116459.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
BACE1
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