1-Methyladenine

1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.

Product Specifications

CAS Number

[5142-22-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-Methyladenine.html

Purity

99.99

Solubility

DMSO : 5 mg/mL (ultrasonic) |H2O : 4.72 mg/mL (ultrasonic; warming; adjust pH to 3 with 1 M HCl; heat to 60°C)

Smiles

NC1=C2N=CN=C2N=CN1C

Molecular Formula

C6H7N5

Molecular Weight

149.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Falnes PØ, et al. Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins. Nucleic Acids Res. 2004 Dec 1;32 (21) :6260-7. Print 2004.|[2]Yang H, et al. Effect of 1-methyladenine on double-helical DNA structures. FEBS Lett. 2008 May 14;582 (11) :1629-33.