Recombinant Human NRP2 Protein (hIgG1 Fc Tag)
Product Specifications
Background
Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2) . NRP2 is important for migration, antigen presentation, phagocytosis and cell-cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells.
Abbreviation
NRP2
Synonyms
PRO; NPN; NRP; neuropilin; vascular endothelial growth factor-165 receptor; VEGF165R; NRP2; NP2; NPN2; PRO2714; VEGF165R2; neuropilin-2; vascular endothelial growth factor-165 receptor 2; MGC126574; Neuropilin 2; Neuropilin2; NP 2; NPN 2; NRP 2; Receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; Vascular endothelial growth factor 165 receptor 2; VEGF1265R2
UniProt
O60462
Accession Number
O60462
Expression System
Mammalian
Tag
C-hIgG1 Fc
Sequence
Val20-Glu855
Field of Research
Cancer; Developmental Biology; Signal Transduction; Cardiovascular
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
116.9 kDa
Observed Molecular Weight
120 kDa
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Species
Human
Available Sizes
Curated Selection
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