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Recombinant Human NRP2 Protein (hIgG1 Fc Tag)

Product Specifications

Background

Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2) . NRP2 is important for migration, antigen presentation, phagocytosis and cell-cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells.

Abbreviation

NRP2

Synonyms

PRO; NPN; NRP; neuropilin; vascular endothelial growth factor-165 receptor; VEGF165R; NRP2; NP2; NPN2; PRO2714; VEGF165R2; neuropilin-2; vascular endothelial growth factor-165 receptor 2; MGC126574; Neuropilin 2; Neuropilin2; NP 2; NPN 2; NRP 2; Receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; Vascular endothelial growth factor 165 receptor 2; VEGF1265R2

UniProt

O60462

Accession Number

O60462

Expression System

Mammalian

Tag

C-hIgG1 Fc

Sequence

Val20-Glu855

Field of Research

Cancer; Developmental Biology; Signal Transduction; Cardiovascular

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

116.9 kDa

Observed Molecular Weight

120 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human

Available Sizes

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