eeAChE-IN-3
Product Specifications
UNSPSC Description
eeAChE-IN-3 (compound YS3g) is an orally active, potent EeAChE and IL-6 inhibitor with IC50s of 0.54 μM, 0.49 μM, 8.54 μM and 0.57 μM for EeAChE, RatAChE, RatBuChE and IL-6, respectively. eeAChE-IN-3 improves STZ (HY-13753) (Streptozotocin; HY-13753)-induced learning and memory impairment in mice. eeAChE-IN-3 has the potential for Alzheimer's disease (AD) research[1].
Target Antigen
Cholinesterase (ChE); Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eeache-in-3.html
Smiles
O=C1C2=C(OC)C=C(OC)C=C2OC(CCCNN3CCNCC3)=C1
Molecular Weight
347.41
References & Citations
[1]Shivam Mishra, et al.Chromone hybrids as interleukin-6 and acetylcholinesterase inhibitor for treatment of Alzheimer's disease: Design, docking, synthesis and evaluation. European Journal of Medicinal Chemistry Reports. Volume 12, December 2024, 100180.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162681/eeAChE-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162681/
Clinical Information
No Development Reported
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