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BRD 4354 (ditrifluoroacetate)

Product Specifications

UNSPSC Description

BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively[1].

Target Antigen

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brd-4354-ditrifluoroacetate.html

Purity

98.52

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Molecular Weight

610.93

References & Citations

[1]Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-112719B/BRD-4354-ditrifluoroacetate-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-112719B/BRD-4354-ditrifluoroacetate-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

Curated Selection

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