Phenylarsine oxide

Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization[1][2].

Product Specifications

CAS Number

[637-03-6]

Product Name Alternative

Oxophenylarsine; PhAsO; Arsenosobenzene

UNSPSC

12352005

Hazard Statement

H301+H331, H410

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/phenylarsine-oxide.html

Purity

99.32

Solubility

DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=[As]C1=CC=CC=C1

Molecular Formula

C6H5AsO

Molecular Weight

168.02

Precautions

H301+H331, H410

References & Citations

[1]A Schmidt, et al. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Proc Natl Acad Sci U S A. 1996 Apr 2;93 (7) :3068-73.|[2]A E Gibson, et al. Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization. Am J Physiol. 1989 Aug;257 (2 Pt 1) :C182-4.