RO5487624

RO5487624, an analogue of RO5464466 (HY-120690), is an orally active hemagglutinin (HA) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus[1].

Product Specifications

CAS Number

[1399103-28-6]

UNSPSC

12352005

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ro5487624.html

Smiles

O=S(C1=CC(NC[C@]2(C)CC(C)(C)C[C@H](O)C2)=CC=C1Cl)(N)=O

Molecular Formula

C16H25ClN2O3S

Molecular Weight

360.90

References & Citations

[1]Zhu L, et al. Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin. PLoS One. 2011;6 (12) :e29120.