BAY-678 (racemate)

BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC) .

Product Specifications

CAS Number

[675103-35-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/BAY-678_racemate.html

Purity

98.30

Solubility

DMSO : ≥ 150 mg/mL

Smiles

N#CC1=NC=C(C(C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1

Molecular Formula

C20H15F3N4O2

Molecular Weight

400.35

Precautions

H302, H315, H319, H335

References & Citations

[1]von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10 (7) :1163-73.