4- (6-Bromo-2-benzothiazolyl) -N-methylbenzenamine

4- (6-Bromo-2-benzothiazolyl) -N-methylbenzenamine is a potent amyloid imaging agent which binds to Amyloid-β (1-40) with a KD of 1.7 nM.

Product Specifications

CAS Number

[566169-98-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4-_6-Bromo-2-benzothiazolyl_-N-methylbenzenamine.html

Purity

98.60

Solubility

10 mM in DMSO

Smiles

CNC1=CC=C(C2=NC3=CC=C(Br)C=C3S2)C=C1

Molecular Formula

C14H11BrN2S

Molecular Weight

319.22

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Mathis CA, et al. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem. 2003 Jun 19;46 (13) :2740-54.|[2]Klunk W, et al. Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies.