Huanglongmycin N

Huanglongmycin N is a DNA topoisomerase I inhibitor (EC50 = 14 μM) .

Product Specifications

CAS Number

[2881024-09-3]

UNSPSC

12352005

Target

Topoisomerase

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/huanglongmycin-n.html

Solubility

10 mM in DMSO

Smiles

OC1=C(CC)C=CC(C2=O)=C1C(C3=C2C=C(C)C(C(C)=O)=C3O)=O

Molecular Formula

C19H16O5

Molecular Weight

324.33

References & Citations

[1]Zhu S, et al. Discovery of a DNA Topoisomerase I Inhibitor Huanglongmycin N and Its Congeners from Streptomyces sp. CB09001. J Org Chem. 2021 Dec 3;86 (23) :16675-16683.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Topo I

Available Sizes

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