Huanglongmycin N
Huanglongmycin N is a DNA topoisomerase I inhibitor (EC50 = 14 μM) .
Product Specifications
CAS Number
[2881024-09-3]
UNSPSC
12352005
Target
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/huanglongmycin-n.html
Solubility
10 mM in DMSO
Smiles
OC1=C(CC)C=CC(C2=O)=C1C(C3=C2C=C(C)C(C(C)=O)=C3O)=O
Molecular Formula
C19H16O5
Molecular Weight
324.33
References & Citations
[1]Zhu S, et al. Discovery of a DNA Topoisomerase I Inhibitor Huanglongmycin N and Its Congeners from Streptomyces sp. CB09001. J Org Chem. 2021 Dec 3;86 (23) :16675-16683.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo I
Available Sizes
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