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Golexanolone

Golexanolone is a GABAA receptor modulating steroid antagonist. Golexanolone reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in hyperammonemic rats[1].

Product Specifications

CAS Number

[2089238-18-4]

Product Name Alternative

GR3027

UNSPSC

12352211

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/golexanolone.html

Smiles

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@](O)(CC2)C#C)([H])[C@@]4([H])[C@](CC3)(/C(CC4)=N/O)C

Molecular Formula

C21H31NO2

Molecular Weight

329.48

References & Citations

[1]Mincheva G, et al. Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation. CNS Neurosci Ther. 2022 Nov;28 (11) :1861-1874.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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