Golexanolone
Golexanolone is a GABAA receptor modulating steroid antagonist. Golexanolone reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in hyperammonemic rats[1].
Product Specifications
CAS Number
2089238-18-4
Product Name Alternative
GR3027
UNSPSC
12352211
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/golexanolone.html
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@](O)(CC2)C#C)([H])[C@@]4([H])[C@](CC3)(/C(CC4)=N/O)C
Molecular Formula
C21H31NO2
Molecular Weight
329.48
References & Citations
[1]Mincheva G, et al. Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation. CNS Neurosci Ther. 2022 Nov;28 (11) :1861-1874.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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