Dianicline (dihydrochloride)

Dianicline dihydrochloride is a α4β2 nicotinic acetylcholine receptor partial agonist, a class of agents that includes varenicline and cytisine for smoking cessation. Dianicline dihydrochloride increases cessation rates in a dose-dependent manner[1].

Product Specifications

CAS Number

[292634-27-6]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dianicline.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

[H][C@]1(CC[N@](CC2)C3)[C@]32CC4=NC=CC=C4O1.[2HCl]

Molecular Formula

C13H18Cl2N2O

Molecular Weight

289.20

References & Citations

[1]Tonstad S, et al. Dianicline, a novel α4β2 nicotinic acetylcholine receptor partial agonist, for smoking cessation: a randomized placebo-controlled clinical trial. Nicotine Tob Res. 2011 Jan;13 (1) :1-6.