PMX 205
PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.
Product Specifications
CAS Number
514814-49-4
UNSPSC
12352209
Hazard Statement
H315, H319, H335, H412
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PMX_205.html
Concentration
10mM
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@](NC(CCC2=CC=CC=C2)=O)([H])CCCNC([C@H](CCCNC(N)=N)NC3=O)=O)=O)=O)CC4CCCCC4)N[C@@]3([H])CC5=CNC6=CC=CC=C56
Molecular Formula
C45H62N10O6
Molecular Weight
839.04
Precautions
H315, H319, H335, H412
References & Citations
[1]Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12 (2) :590-6.|[2]Woodruff TM, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181 (12) :8727-34.|[3]Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183 (2) :1375-83.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cell Mol Neurobiol. 2023 Jul;43 (5) :1957-1974.|Cell Rep. 2023 Mar 15;42 (3) :112240.|Mol Neurobiol. 2025 Jul 10.|Theranostics. 2019 Oct 12;9 (25) :7566-7582. |Adv Sci (Weinh) . 2024 Jun 5:e2400819.|bioRxiv. 2025 Aug 28:2025.08.22.671883.|Cell Death Dis. 2024 Oct 5;15 (10) :729.|Clin Immunol. 2025 Apr:273:110459.|Int J Cancer. 2023 Jul 1;153 (1) :224-237.|La Trobe University. 2022 Jan.|Nature. 2025 Sep;645 (8082) :1051-1059.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040158-100 1x 100 µL
Cytokeratin 17 (E3), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471081-100 1x 100 µL
CD45RO (190-2F2.5), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC742992-100 1x 100 µL
MUC3 (Mucin 3) (MUC3/2992R), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740257-100 1x 100 µL
Cytokeratin, HMW (AE-3), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details