Pulrodemstat (benzenesulfonate)

CC-90011 benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. CC-90011 benzenesulfonate is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. CC-90011 benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].

Product Specifications

CAS Number

[2097523-60-7]

Product Name Alternative

CC-90011 (benzenesulfonate) ; LSD1-IN-7 (benzenesulfonate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lsd1-in-7-benzenesulfonate.html

Concentration

10mM

Purity

99.64

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.O=S(C5=CC=CC=C5)(O)=O

Molecular Formula

C30H29F2N5O5S

Molecular Weight

609.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1) . J Med Chem. 2020 Dec 10;63 (23) :14522-14529.