Pulrodemstat (benzenesulfonate)
Product Specifications
Product Name Alternative
CC-90011 (benzenesulfonate); LSD1-IN-7 (benzenesulfonate)
UNSPSC Description
CC-90011 benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. CC-90011 benzenesulfonate is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. CC-90011 benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].
Target Antigen
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-in-7-benzenesulfonate.html
Purity
99.64
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.O=S(C5=CC=CC=C5)(O)=O
Molecular Weight
609.64
References & Citations
[1]Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129388B/Pulrodemstat-benzenesulfonate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129388B/Pulrodemstat-benzenesulfonate-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
2097523-60-7
Available Sizes
Curated Selection
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