Danegaptide

Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].

Product Specifications

CAS Number

[943134-39-2]

Product Name Alternative

GAP-134; ZP 1609

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Gap Junction Protein

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gap-134.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@H]1CN(C(CN)=O)[C@H](C(O)=O)C1)C2=CC=CC=C2

Molecular Formula

C14H17N3O4

Molecular Weight

291.30

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]John A Butera, et al. Discovery of (2S,4R) -1- (2-aminoacetyl) -4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134) 13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation. J Med Chem. 2009 Feb 26;52 (4) :908-11.|[2]Elke De Vuyst, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163 (3) :469-83.