Masupirdine (free base)

Masupirdine free base (SUVN-502 free base) is a potent, selective, orally active, and brain-penetrating 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor) . Masupirdine free base has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine (HY-N0296), MK-801 (HY-15084B) -induced and aging-related memory deficits. Masupirdine free base can be used in the research of Alzheimer's disease[1][2].

Product Specifications

CAS Number

[701205-60-9]

Product Name Alternative

SUVN-502 (free base)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/masupirdine-free-base.html

Solubility

10 mM in DMSO

Smiles

O=S(N1C2=CC=C(OC)C=C2C(CN3CCN(C)CC3)=C1)(C(C=CC=C4)=C4Br)=O

Molecular Formula

C21H24BrN3O3S

Molecular Weight

478.40

References & Citations

[1]Nirogi R, et al. Discovery and Development of 1-[ (2-Bromophenyl) sulfonyl]-5-methoxy-3-[ (4-methyl-1-piperazinyl) methyl]-1H-indole Dimesylate Monohydrate (SUVN-502) : A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60 (5) :1843-1859.|[2]Nirogi R, et al. SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization. Behav Pharmacol. 2019 Feb;30 (1) :16-35.