Duocarmycin MB
Duocarmycin MB is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-agent resistant cell lines.
Product Specifications
CAS Number
1613286-58-0
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/duocarmycin-mb.html
Solubility
10 mM in DMSO
Smiles
ClC[C@H]1C2=C(C=C(O)C3=CC=CC=C23)N(C(C4=CC5=CC=C(NC(OC(C)(C)C)=O)C=C5N4)=O)C1
Molecular Formula
C27H26ClN3O4
Molecular Weight
491.97
References & Citations
[1]Searcey M. Duocarmycins--natures prodrugs? Curr Pharm Des. 2002;8 (15) :1375-89.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Duocarmycins
Frequently Asked Questions
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