What is the catalog number for SNAP 94847?

The catalog number for SNAP 94847 is HY-107625.

What sizes are available for SNAP 94847?

SNAP 94847 is available in the following size(s): 1 Each.

Is SNAP 94847 in stock?

SNAP 94847 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SNAP 94847?

SNAP 94847 is manufactured by QuantiMol.

What is the estimated delivery time for SNAP 94847?

Estimated delivery time for SNAP 94847 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SNAP 94847?

The safety data sheet for SNAP 94847 is available here: http://file.medchemexpress.com/batch_PDF/HY-107625/.

SNAP 94847

SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters[1][3].

Product Specifications

CAS Number

487051-12-7

UNSPSC

12352005

Hazard Statement

H410

Target

MCHR1 (GPR24)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/snap-94847.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(NC(C(C)C)=O)C=C1C2CCN(CC3=CC=C(OC4=CC(F)=C(F)C=C4)C=C3)CC2

Molecular Formula

C29H32F2N2O2

Molecular Weight

478.57

Precautions

P273-P391-P501

References & Citations

[1]David DJ, et al. Efficacy of the MCHR1 antagonist N-[3- (1-{[4- (3,4-difluorophenoxy) phenyl]methyl} (4-piperidyl) ) -4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther. 2007 Apr;321 (1) :237-48. Epub 2007 Jan 19.|[2]Nair SG, et al. Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats.Psychopharmacology (Berl) . 2009 Jul;205 (1) :129-40.|[3]Chen CA, et al. Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.J Med Chem. 2007 Aug 9;50 (16) :3883-90.