SNAP 94847

SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters[1][3].

Product Specifications

CAS Number

[487051-12-7]

UNSPSC

12352005

Hazard Statement

H410

Target

MCHR1 (GPR24)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/snap-94847.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=C(NC(C(C)C)=O)C=C1C2CCN(CC3=CC=C(OC4=CC(F)=C(F)C=C4)C=C3)CC2

Molecular Formula

C29H32F2N2O2

Molecular Weight

478.57

Precautions

P273-P391-P501

References & Citations

[1]David DJ, et al. Efficacy of the MCHR1 antagonist N-[3- (1-{[4- (3,4-difluorophenoxy) phenyl]methyl} (4-piperidyl) ) -4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther. 2007 Apr;321 (1) :237-48. Epub 2007 Jan 19.|[2]Nair SG, et al. Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats.Psychopharmacology (Berl) . 2009 Jul;205 (1) :129-40.|[3]Chen CA, et al. Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits.J Med Chem. 2007 Aug 9;50 (16) :3883-90.