LY367385

LY367385 is a highly selective and potent mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects[1][2].

Product Specifications

CAS Number

[198419-91-9]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly367385.html

Purity

99.0

Solubility

H2O : 10 mg/mL (ultrasonic)

Smiles

OC([C@H](C1=C(C=C(C(O)=O)C=C1)C)N)=O

Molecular Formula

C10H11NO4

Molecular Weight

209.20

References & Citations

[1]Clark et al. (+) -2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21) : 2777-2780.|[2]Bruno V, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+) -2-methyl-4 carboxyphenylglycine (LY367385) : comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. 1999 Feb;38 (2) :199-207.|[3]Chapman AG, et al. Anticonvulsant actions of LY 367385 ((+) -2-methyl-4-carboxyphenylglycine) and AIDA ((RS) -1-aminoindan-1,5-dicarboxylic acid) . Eur J Pharmacol. 1999 Feb 26;368 (1) :17-24.