LY367385
LY367385 is a highly selective and potent mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects[1][2].
Product Specifications
CAS Number
198419-91-9
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly367385.html
Purity
99.0
Solubility
H2O : 10 mg/mL (ultrasonic)
Smiles
OC([C@H](C1=C(C=C(C(O)=O)C=C1)C)N)=O
Molecular Formula
C10H11NO4
Molecular Weight
209.20
References & Citations
[1]Clark et al. (+) -2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21) : 2777-2780.|[2]Bruno V, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+) -2-methyl-4 carboxyphenylglycine (LY367385) : comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. 1999 Feb;38 (2) :199-207.|[3]Chapman AG, et al. Anticonvulsant actions of LY 367385 ((+) -2-methyl-4-carboxyphenylglycine) and AIDA ((RS) -1-aminoindan-1,5-dicarboxylic acid) . Eur J Pharmacol. 1999 Feb 26;368 (1) :17-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1
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