Thalidomide-O-amido-C4-NH2

Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Product Specifications

CAS Number

[1799711-24-2]

Product Name Alternative

Cereblon Ligand-Linker Conjugates 6; E3 Ligase Ligand-Linker Conjugates 19

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dBRD9-1.html

Solubility

10 mM in DMSO

Smiles

NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O

Molecular Formula

C19H22N4O6

Molecular Weight

402.40

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61 (2) :462-481.|[2]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.