Barnidipine

Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance[1][2][3].

Product Specifications

CAS Number

[104713-75-9]

Product Name Alternative

Mepirodipine; YM-09730-5 (Free base)

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/barnidipine.html

Purity

98.97

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC(C)=C(C(O[C@@H]2CN(CC3=CC=CC=C3)CC2)=O)[C@H]1C4=CC=CC([N+]([O-])=O)=C4)OC

Molecular Formula

C27H29N3O6

Molecular Weight

491.54

References & Citations

[1]van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8|[2]Malhotra HS, et al. Barnidipine. Drugs. 2001;61 (7) :989-96; discussion 997-8.|[3]Hashimoto M, et al. Treatment with a Ca (2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Am J Nephrol. 1999;19 (5) :615-21.