Antitrypanosomal agent 1

Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM) . Antitrypanosomal agent 1 has anti-trypanosomal activity[1].

Product Specifications

CAS Number

[75144-12-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antitrypanosomal-agent-1.html

Purity

99.50

Solubility

DMSO : 14.58 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 10 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(Cl)C(Cl)=C1)CCN(C)C.[H]Cl

Molecular Formula

C11H14Cl3NO

Molecular Weight

282.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17 (5) :1280-3.