GW3965
GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].
Product Specifications
CAS Number
[405911-09-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
LXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/GW3965.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4
Molecular Formula
C33H31ClF3NO3
Molecular Weight
582.05
Precautions
H302, H315, H319, H335
References & Citations
[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60 (6), 616-621.|[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1 (5), 442-456.|[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117 (21), 5751-5761.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Am J Physiol Endocrinol Metab. 2019 Jun 1;316 (6) :E1136-E1145. |Bioconjug Chem. 2015 Nov 18;26 (11) :2216-22. |Biogerontology. 2025 Jan 31;26 (2) :49.|Brain Behav Immun. 2025 Aug 21:106089.|Cancer Lett. 2023 Jun 28:564:216208.|Cell Death Differ. 2020 Aug;27 (8) :2433-2450. |J Am Heart Assoc. 2021 May 18;10 (10) :e018455.|J Ethnopharmacol. 2023 Oct 28:315:116684.|MedComm (2020) . 2025 Sep 27;6 (10) :e70411.|Sci Adv. 2022 Jul 15;8 (28) :eabn5295.|SSRN. 2025 Aug 13.|Theranostics. 2020 Jul 11;10 (19) :8834-8850. |Vet Microbiol. 2024 Jan:288:109948.|bioRxiv. 2023 Mar 10.|Cytokine. 2025 May 7:191:156955.|Environ Int. 2024 Nov 26:194:109168.|Environ Sci Technol. 2025 May 6;59 (17) :8439-8450.|Immun Inflamm Dis. 2025 Aug;13 (8) :e70243.|Int Immunopharmacol. 2026 Jan 1;168 (Pt 2) :115878.|J Transl Med. 2025 May 14;23 (1) :542.|Nat Commun. 2025 Nov 6;16 (1) :9805.|Radboud University Nijmegen. 2021 Mar.|Viruses. 2022 Mar 3;14 (3) :514.
Available Sizes
Curated Selection
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