SKF-82958
SKF-82958 ((±) -SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM) . SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM) [1].
Product Specifications
CAS Number
80751-65-1
Product Name Alternative
(±) -SKF-82958; Chloro-APB
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SKF-82958.html
Solubility
10 mM in DMSO
Smiles
OC1=C(O)C=C2C(C3=CC=CC=C3)CN(CC=C)CCC2=C1Cl
Molecular Formula
C19H20ClNO2
Molecular Weight
329.82
References & Citations
[1]Mottola DM, et al. Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. J Med Chem. 1996;39 (1) :285-296.|[2]Haile CN, et al. The dopamine D (1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat. Eur J Pharmacol. 2000;388 (2) :125-131.|[3]Mayorga AJ, et al. Striatal and nigral D1 mechanisms involved in the antiparkinsonian effects of SKF-82958 (APB) : studies of tremulous jaw movements in rats. Psychopharmacology (Berl) . 1999;143 (1) :72-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor
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