Fasudil
Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca2+ channel antagonist and vasodilator[1][2][3].
Product Specifications
CAS Number
103745-39-7
Product Name Alternative
HA-1077; AT877
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Calcium Channel; PKA; PKC; ROCK
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fasudil.html
Purity
99.91
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O
Molecular Formula
C14H17N3O2S
Molecular Weight
291.37
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PKA; PKC; ROCK1; ROCK2
Citation 01
Available Sizes
Frequently Asked Questions
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