Duvakitug
Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS) . Duvakitug can be used in the study of Crohn's Disease (CD) [1][2].
Product Specifications
CAS Number
2750005-84-4
Product Name Alternative
TEV-48574
UNSPSC
12352203
Target
TNF Receptor
Type
Inhibitory Antibodies
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/duvakitug.html
Purity
99.76
Solubility
10 mM in DMSO
Smiles
[Duvakitug]
Molecular Weight
(143.64 kDa)
References & Citations
[1]Duvakitug. IMGT/mAb-DB.|[2]Gonsky, et al. Intestinal mononuclear phagocytes as prognostic biomarker for Crohn's disease. World Intellectual Property Organization, WO2023102051 A1. 2023-06-08.|[3]Reinisch W, et al. OP41 Duvakitug (TEV-48574), an anti-TL1a monoclonal antibody, demonstrates efficacy and favourable safety as an induction treatment in adults with moderately to severely active ulcerative colitis: Results from a phase 2b, randomised, double-blind, placebo-controlled, dose-ranging, basket trial (RELIEVE UCCD) [J]. Journal of Crohn's and Colitis, 2025, 19 (Supplement_1) : i79-i80.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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