Duvakitug

Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS) . Duvakitug can be used in the study of Crohn's Disease (CD) [1][2].

Product Specifications

CAS Number

[2750005-84-4]

Product Name Alternative

TEV-48574

UNSPSC

12352203

Target

TNF Receptor

Type

Inhibitory Antibodies

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/duvakitug.html

Purity

99.76

Solubility

10 mM in DMSO

Smiles

[Duvakitug]

Molecular Weight

(143.64 kDa)

References & Citations

[1]Duvakitug. IMGT/mAb-DB.|[2]Gonsky, et al. Intestinal mononuclear phagocytes as prognostic biomarker for Crohn's disease. World Intellectual Property Organization, WO2023102051 A1. 2023-06-08.|[3]Reinisch W, et al. OP41 Duvakitug (TEV-48574), an anti-TL1a monoclonal antibody, demonstrates efficacy and favourable safety as an induction treatment in adults with moderately to severely active ulcerative colitis: Results from a phase 2b, randomised, double-blind, placebo-controlled, dose-ranging, basket trial (RELIEVE UCCD) [J]. Journal of Crohn's and Colitis, 2025, 19 (Supplement_1) : i79-i80.