Ryanodine

Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

Product Specifications

CAS Number

[15662-33-6]

UNSPSC

12352005

Hazard Statement

H302+H312, H410

Target

Calcium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ryanodine.html

Purity

99.35

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@@]1([C@@]([C@@]2(O)O3)4C)[C@@]35[C@](O)(CC[C@H](C)[C@H]5O)[C@@](C2)(C)[C@@]1([C@H](OC(C6=CC=CN6)=O)[C@]4(O)C(C)C)O

Molecular Formula

C25H35NO9

Molecular Weight

493.55

Precautions

H302+H312, H410

References & Citations

[1]Meissner G, et al. Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum. J Biol Chem. 1986 May 15;261 (14) :6300-6.|[2]Fryer MW, et al. The action of ryanodine on rat fast and slow intact skeletal muscles. J Physiol. 1989 Jul;414:399-413.