MRE3008F20

MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM) . MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R[1][2].

Product Specifications

CAS Number

[252979-43-4]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mre3008f20.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(OC)C=C1)NC2=NC3=NN(CCC)C=C3C4=NC(C5=CC=CO5)=NN24

Molecular Formula

C21H20N8O3

Molecular Weight

432.44

References & Citations

[1]Gessi S, et al. Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol Pharmacol. 2004 Mar;65 (3) :711-9.|[2]Baraldi P G, et al. New potent and selective human adenosine A3 receptor antagonists. Trends in pharmacological sciences, 2000, 21 (12) : 456-459.