MRE3008F20
MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM) . MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R[1][2].
Product Specifications
CAS Number
252979-43-4
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mre3008f20.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(OC)C=C1)NC2=NC3=NN(CCC)C=C3C4=NC(C5=CC=CO5)=NN24
Molecular Formula
C21H20N8O3
Molecular Weight
432.44
References & Citations
[1]Gessi S, et al. Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol Pharmacol. 2004 Mar;65 (3) :711-9.|[2]Baraldi P G, et al. New potent and selective human adenosine A3 receptor antagonists. Trends in pharmacological sciences, 2000, 21 (12) : 456-459.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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