NPS ALX Compound 4a

NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM[1].

Product Specifications

CAS Number

[299433-10-6]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nps-alx-compound-4a.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=S(N1C=CC2=C1C=C(N3CC(CCC4)N4CC3)C=C2)(C5=C6C=CC=CC6=CC=C5)=O

Molecular Formula

C25H25N3O2S

Molecular Weight

431.55

References & Citations

[1]Isaac M, et al. 6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindolesderivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2000 Aug 7;10 (15) :1719-21.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT6 Receptor; MUC2

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