PD 123319
PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
Product Specifications
CAS Number
130663-39-7
Product Name Alternative
(S) - (+) -PD 123319
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/pd-123319.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O
Molecular Formula
C31H32N4O3
Molecular Weight
508.61
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Blankley CJ, et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991 Nov;34 (11) :3248-60.|[2]Boulay G, et al. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol Pharmacol. 1992 Apr;41 (4) :809-15|[3]Estrup TM, et al. No effect of angiotensin II AT (2) -receptor antagonist PD 123319 on cerebral blood flow autoregulation. J Renin Angiotensin Aldosterone Syst. 2001 Sep;2 (3) :188-92.|[4]Brillante DG, et al. Effects of intravenous PD 123319 on haemodynamic and arterial stiffness indices in healthy volunteers. J Renin Angiotensin Aldosterone Syst. 2005 Sep;6 (2) :102-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT2 Receptor
Citation 01
Acta Pharmacol Sin. 2024 Jun;45 (6) :1201-1213.|FASEB J. 2019 May;33 (5) :6254-6268. |Int Immunopharmacol. 2022 Sep:110:108921.|J Exp Med. 2022 Mar 7;219 (3) :e20211001.|Redox Biol. 2021 Oct:46:102115|Rep Biochem Mol Biol. 2021 Jul;10 (2) :314-326.|SSRN. 13 Apr 2022.|Clin Transl Med. 2025 Jun;15 (6) :e70361.|FASEB J. 2018 Sep;32 (9) :5051-5062.|Neurosci Lett. 2025 Aug 28:138369.
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