Refametinib (R enantiomer)
Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC50 of 2.0-15 nM.
Product Specifications
CAS Number
923032-38-6
Product Name Alternative
BAY 869766 R enantiomer; RDEA119 R enantiomer
UNSPSC
12352005
Hazard Statement
H361-H372
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Refametinib-R-enantiomer.html
Solubility
10 mM in DMSO
Smiles
O=S(C1(C[C@H](CO)O)CC1)(NC(C(NC(C(F)=C2)=CC=C2I)=C3F)=C(OC)C=C3F)=O
Molecular Formula
C19H20F3IN2O5S
Molecular Weight
572.34
Precautions
P260-P264-P270-P280-P405-P501
References & Citations
[1]Andreas Maderna, et al. N- (arylamino) -sulfonamide inhibitors of mek. WO 2007014011 A2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK
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